Passive Tumor Targeting

The endothelium (innermost cell layer) of tumor capillaries is less well organized and have more numerous and larger pores than normal healthy vessels
Nanoparticles with a suitable size stay in the blood stream until reaching tumor tissue where they selectively leak into the tumor tissue. This gives a larger difference in concentration of the nanoparticle based contrast agent in tumor tissue compared to normal tissue and hence higher contrast (more white on darker background) than for small molecule based contrast agents.

SPAGO Imaging’s compact nanostructures have a size suitable for passive tumor targeting and renal excretion.